Who We Are
Our lab specializes in analysis of the extremely polymorphic human leukocyte antigen (HLA) and killer immunoglobulin-like receptor (KIR) immunogenetic systems. In addition to their critical role in transplantation, over 100 infectious, autoimmune and pharmacological disease phenotypes and cancers are associated with genetic variation of HLA and KIR, which also have functional interaction with one another.
What We Do
Our work spans the population genetics, evolutionary history, and influence on human health of these complex genomic regions, with particular emphasis on their role in neurological disease. We are also engaged in the development of community standards and software tools for these highly variable immunogenetic data.
Proud moment from #EFI2025 this May! 📸
Sharing glimpses of our amazing lab mates presenting their work at the EFI Conference — exciting findings, great discussions, and unforgettable memories. 🌟 pic.twitter.com/w65gz1lyou— Hollenbach Lab (@hollenbachlab) June 24, 2025
Congratulations to Jacqueline Williams and all the authors on their recent study on the association between C4 gene variation and multiple sclerosis (MS), offering new insights into the complement system’s role in MS.
📖 Read more: https://t.co/0mxy4dlbqt— Hollenbach Lab (@hollenbachlab) March 20, 2025
Exciting new research from the Hollenbach Lab! This study explores the intricate relationship between HLA and CMV in The American Journal of Human Genetics. Check it out here: https://t.co/E5Y7esIUN9 #HLA #CMV #Immunogenetics #Genomics #AJHG https://t.co/co66HpurSb pic.twitter.com/bqWZ5Ojk7d
— Hollenbach Lab (@hollenbachlab) March 13, 2025
