Jill Hollenbach, PhD, MPH

Professor
Department of Neurology
Department of Epidemiology and Biostatistics
[email protected]

Jill Hollenbach is  Professor in the Department of Neurology and Department of Epidemiology and Biostatistics at the University of California, San Francisco. She was raised in California and completed her undergraduate studies in Physiology and Master’s degree in Public Health at the University of California, Berkeley. After several years working in public health in the Caribbean and Bay Area, she returned to UC Berkeley for her doctoral studies in Immunology, with an emphasis on population genetics of the human leukocyte antigen (HLA) system. Throughout her career Dr. Hollenbach’s work has continued to focus on the HLA loci and related systems such as the killer immunoglobulin-like receptor (KIR) genes in disease association, transplantation and evolutionary studies. She has also been deeply involved in the establishment of community standards and software development for immunogenetic data management and analysis and is a Councilor of the International HLA and Immunogenetics Council and Associate Editor for disease association studies at HLA Journal. Dr. Hollenbach’s laboratory at UCSF applies study of these complex systems to advance efforts to elucidate the genetic basis of underlying immune dysregulation in neurological, autoimmune, and infectious disease.

UCSF Profiles

UCSF Bioinformatics Graduate Program

UCSF Institute for Human Genetics

UCSF Multiple Sclerosis Research Group

Women In Science @UCSF

Immunogenomic Data Analysis Working Group (IDAWG)

International Histocompatibility and Immunogenetics Workshop Council

 

Publications: 

MHConstructor: a high-throughput, haplotype-informed solution to the MHC assembly challenge.

Genome biology

Wade KJ, Suseno R, Kizer K, Williams J, Boquett J, Caillier S, Pollock NR, Renschen A, Santaniello A, Oksenberg JR, Norman PJ, Augusto DG, Hollenbach JA

Multiple measures for self-identification improve matching donors with patients in unrelated hematopoietic stem cell transplant.

Communications medicine

Damotte V, Zhao C, Lin C, Williams E, Louzoun Y, Madbouly A, Kotlarz R, McDaniel M, Norman PJ, Wang Y, Maiers M, Hollenbach JA

Antigen-specificity of clonally-enriched CD8+ T cells in multiple sclerosis.

bioRxiv : the preprint server for biology

Mittl K, Hayashi F, Dandekar R, Schubert RD, Gerdts J, Oshiro L, Loudermilk R, Greenfield A, Augusto DG, Ramesh A, Tran E, Koshal K, Kizer K, Dreux J, Cagalingan A, Schustek F, Flood L, Moore T, Kirkemo LL, Cooper T, Harms M, Gomez R, University of California, San Francisco MS-EPIC Team, Sibener L, Cree BAC, Hauser SL, Hollenbach JA, Gee M, Wilson MR, Zamvil SS, Sabatino JJ

The most frequent HLA alleles around the world: A fundamental synopsis.

Best practice & research. Clinical haematology

Sanchez-Mazas A, Nunes JM, PGAE HLA Consortium of the 18th International HLA and Immunogenetics Workshop

The 18th International HLA & Immunogenetics workshop project report: Creating fully representative MHC reference haplotypes.

HLA

Pollock NR, Farias TDJ, Kichula KM, Sauter J, Scholz S, Nii-Trebi NI, Khor SS, Tokunaga K, Voorter CE, Groeneweg M, Augusto DG, Arrieta-Bolaños E, Mayor NP, Edinur HA, ElGhazali G, Issler HC, Petzl-Erler ML, Oksenberg JR, Marin WM, Hollenbach JA, Gendzekhadze K, Cita R, Stelet V, Rajalingam R, Koskela S, Clancy J, Chatzistamatiou T, Houwaart T, Kulski J, Guethlein LA, Parham P, Schmidt AH, Dilthey A, Norman PJ

MHConstructor: A high-throughput, haplotype-informed solution to the MHC assembly challenge.

bioRxiv : the preprint server for biology

Wade KJ, Suseno R, Kizer K, Williams J, Boquett J, Caillier S, Pollock NR, Renschen A, Santaniello A, Oksenberg JR, Norman PJ, Augusto DG, Hollenbach JA

An autoantibody signature predictive for multiple sclerosis.

Nature medicine

Zamecnik CR, Sowa GM, Abdelhak A, Dandekar R, Bair RD, Wade KJ, Bartley CM, Kizer K, Augusto DG, Tubati A, Gomez R, Fouassier C, Gerungan C, Caspar CM, Alexander J, Wapniarski AE, Loudermilk RP, Eggers EL, Zorn KC, Ananth K, Jabassini N, Mann SA, Ragan NR, Santaniello A, Henry RG, Baranzini SE, Zamvil SS, Sabatino JJ, Bove RM, Guo CY, Gelfand JM, Cuneo R, von Büdingen HC, Oksenberg JR, Cree BAC, Hollenbach JA, Green AJ, Hauser SL, Wallin MT, DeRisi JL, Wilson MR

High-resolution DNA methylation screening of the major histocompatibility complex in multiple sclerosis.

Frontiers in neurology

Ma Q, Augusto DG, Montero-Martin G, Caillier SJ, Osoegawa K, Cree BAC, Hauser SL, Didonna A, Hollenbach JA, Norman PJ, Fernandez-Vina M, Oksenberg JR

HLA-DPB1*013:01 associates with enhanced, and KIR2DS4*001 with diminished protection from developing severe COVID-19.

HLA

Farias TDJ, Brugiapaglia S, Croci S, Magistroni P, Curcio C, Zguro K, Fallerini C, Fava F, Pettini F, Kichula KM, Pollock NR, Font-Porterias N, Palmer WH, Marin WM, Baldassarri M, Bruttini M, Hollenbach JA, Hendricks AE, Meloni I, Novelli F, GEN-COVID Multicenter Study Group, Renieri A, Furini S, Norman PJ, Amoroso A

Exceptional diversity of KIR and HLA class I in Egypt.

HLA

Montero-Martin G, Kichula KM, Misra MK, de Brito Vargas L, Marin WM, Hollenbach JA, Fernández-Viña MA, Elfishawi S, Norman PJ

A common allele of HLA is associated with asymptomatic SARS-CoV-2 infection.

Nature

Augusto DG, Murdolo LD, Chatzileontiadou DSM, Sabatino JJ, Yusufali T, Peyser ND, Butcher X, Kizer K, Guthrie K, Murray VW, Pae V, Sarvadhavabhatla S, Beltran F, Gill GS, Lynch KL, Yun C, Maguire CT, Peluso MJ, Hoh R, Henrich TJ, Deeks SG, Davidson M, Lu S, Goldberg SA, Kelly JD, Martin JN, Vierra-Green CA, Spellman SR, Langton DJ, Dewar-Oldis MJ, Smith C, Barnard PJ, Lee S, Marcus GM, Olgin JE, Pletcher MJ, Maiers M, Gras S, Hollenbach JA

Genotype List String 1.1: Extending the Genotype List String grammar for describing HLA and Killer-cell Immunoglobulin-like Receptor genotypes.

HLA

Mack SJ, Schefzyk D, Millius RP, Maiers M, Hollenbach JA, Pollack J, Heuer ML, Gragert L, Spellman SR, Guethlein LA, Schneider J, Bochtler W, Eberhard HP, Robinson J, Marsh SGE, Schmidt AH, Hofmann JA, Sauter J

Adeno-associated virus 2 infection in children with non-A-E hepatitis.

Nature

Ho A, Orton R, Tayler R, Asamaphan P, Herder V, Davis C, Tong L, Smollett K, Manali M, Allan J, Rawlik K, McDonald SE, Vink E, Pollock L, Gannon L, Evans C, McMenamin J, Roy K, Marsh K, Divala T, Holden MTG, Lockhart M, Yirrell D, Currie S, O'Leary M, Henderson D, Shepherd SJ, Jackson C, Gunson R, MacLean A, McInnes N, Bradley-Stewart A, Battle R, Hollenbach J, Henderson P, Odam M, Chikowore P, Oosthuyzen W, Chand M, Hamilton MS, Estrada-Rivadeneyra D, Levin M, Avramidis N, Pairo-Castineira E, Vitart V, Wilkie C, DIAMONDS consortium, ISARIC4C investigators, Palmarini M, Ray S, Robertson DL, da Silva Filipe A, Willett BJ, Breuer J, Semple MG, Turner D, Baillie JK, Thomson EC

The immunogenetics of COVID-19.

Immunogenetics

Hollenbach JA, Srivastava A

Interaction between maternal killer immunoglobulin-like receptors and offspring HLAs and susceptibility of childhood ALL.

Blood advances

Feng Q, Zhou M, Li S, Morimoto LM, Hansen HM, Myint SS, Wang R, Metayer C, Kang AY, Fear AL, Pappas D, Erlich H, Hollenbach JA, Mancuso N, Trachtenberg E, de Smith AJ, Ma X, Wiemels JL

HLA variation and antigen presentation in COVID-19 and SARS-CoV-2 infection.

Current opinion in immunology

Augusto DG, Hollenbach JA

A short HLA-DRA isoform binds the HLA-DR2 heterodimer on the outer domain of the peptide-binding site.

Archives of biochemistry and biophysics

Shams H, Hollenbach JA, Matsunaga A, Mofrad MRK, Oksenberg JR, Didonna A

Minimal observed impact of HLA genotype on hospitalization and severity of SARS-CoV-2 infection.

HLA

Nguyen A, Yusufali T, Hollenbach JA, Nellore A, Thompson RF

Multiple sclerosis therapies differentially impact SARS-CoV-2 vaccine-induced antibody and T cell immunity and function.

JCI insight

Sabatino JJ, Mittl K, Rowles WM, McPolin K, Rajan JV, Laurie MT, Zamecnik CR, Dandekar R, Alvarenga BD, Loudermilk RP, Gerungan C, Spencer CM, Sagan SA, Augusto DG, Alexander JR, DeRisi JL, Hollenbach JA, Wilson MR, Zamvil SS, Bove R

Remarkably low KIR and HLA diversity in Amerindians reveals signatures of strong purifying selection shaping the centromeric KIR region.

Molecular biology and evolution

Vargas LB, Beltrame MH, Ho B, Marin WM, Dandekar R, Montero-Martín G, Fernández-Viña MA, Hurtado AM, Hill KR, Tsuneto LT, Hutz MH, Salzano FM, Petzl-Erler ML, Hollenbach JA, Augusto DG

HLA-A Locus is Associated With Sepsis and Septic Shock After Traumatic Injury.

Annals of surgery

Horn DL, Mindrinos M, Anderson K, Krishnakumar S, Wang C, Li M, Hollenbach J, O'Keefe GE

Approaching Genetics Through the MHC Lens: Tools and Methods for HLA Research.

Frontiers in genetics

Douillard V, Castelli EC, Mack SJ, Hollenbach JA, Gourraud PA, Vince N, Limou S

Current HLA Investigations on SARS-CoV-2 and Perspectives.

Frontiers in genetics

Douillard V, Castelli EC, Mack SJ, Hollenbach JA, Gourraud PA, Vince N, Limou S, Covid-19|HLA & Immunogenetics Consortium and the SNP-HLA Reference Consortium

Severe delayed hypersensitivity reactions to IL-1 and IL-6 inhibitors link to common HLA-DRB1*15 alleles.

Annals of the rheumatic diseases

Saper VE, Ombrello MJ, Tremoulet AH, Montero-Martin G, Prahalad S, Canna S, Shimizu C, Deutsch G, Tan SY, Remmers EF, Monos D, Hahn T, Phadke OK, Cassidy E, Ferguson I, Mallajosyula V, Xu J, Rosa Duque JS, Chua GT, Ghosh D, Szymanski AM, Rubin D, Burns JC, Tian L, Fernandez-Vina MA, Mellins ED, Hollenbach JA, Drug Hypersensitivity Consortium, INCHARGE Consortium

Analysis of genomic DNA from medieval plague victims suggests long-term effect of Yersinia pestis on human immunity genes.

Molecular biology and evolution

Immel A, Key FM, Szolek A, Barquera R, Robinson MK, Harrison GF, Palmer WH, Spyrou MA, Susat J, Krause-Kyora B, Bos KI, Forrest S, Hernández-Zaragoza DI, Sauter J, Solloch U, Schmidt AH, Schuenemann VJ, Reiter E, Kairies MS, Weiß R, Arnold S, Wahl J, Hollenbach JA, Kohlbacher O, Herbig A, Norman PJ, Krause J

An immunogenetic view of COVID-19.

Genetics and molecular biology

Aguiar VRC, Augusto DG, Castelli EC, Hollenbach JA, Meyer D, Nunes K, Petzl-Erler ML

Identifying falls remotely in people with multiple sclerosis.

Journal of neurology

Block VJ, Pitsch EA, Gopal A, Zhao C, Pletcher MJ, Marcus GM, Olgin JE, Hollenbach J, Bove R, Cree BAC, Gelfand JM

High-throughput Interpretation of Killer-cell Immunoglobulin-like Receptor Short-read Sequencing Data with PING.

PLoS computational biology

Marin WM, Dandekar R, Augusto DG, Yusufali T, Heyn B, Hofmann J, Lange V, Sauter J, Norman PJ, Hollenbach JA

Following Transplantation for Acute Myelogenous Leukemia, Donor KIR Cen B02 Better Protects against Relapse than KIR Cen B01.

Journal of immunology (Baltimore, Md. : 1950)

Guethlein LA, Beyzaie N, Nemat-Gorgani N, Wang T, Ramesh V, Marin WM, Hollenbach JA, Schetelig J, Spellman SR, Marsh SGE, Cooley S, Weisdorf DJ, Norman PJ, Miller JS, Parham P

Large-Scale Imputation of KIR Copy Number and HLA Alleles in North American and European Psoriasis Case-Control Cohorts Reveals Association of Inhibitory KIR2DL2 With Psoriasis.

Frontiers in immunology

Ahn R, Vukcevic D, Motyer A, Nititham J, Squire DM, Hollenbach JA, Norman PJ, Ellinghaus E, Nair RP, Tsoi LC, Oksenberg J, Foerster J, Lieb W, Weidinger S, Franke A, Elder JT, Jorgenson E, Leslie S, Liao W

Next-Generation Sequencing Identifies Extended HLA Class I and II Haplotypes Associated With Early-Onset and Late-Onset Myasthenia Gravis in Italian, Norwegian, and Swedish Populations.

Frontiers in immunology

Creary LE, Gangavarapu S, Caillier SJ, Cavalcante P, Frangiamore R, Lie BA, Bengtsson M, Harbo HF, Brauner S, Hollenbach JA, Oksenberg JR, Bernasconi P, Maniaol AH, Hammarström L, Mantegazza R, Fernández-Viña MA

High Resolution Haplotype Analyses of Classical HLA Genes in Families With Multiple Sclerosis Highlights the Role of HLA-DP Alleles in Disease Susceptibility.

Frontiers in immunology

Osoegawa K, Creary LE, Montero-Martín G, Mallempati KC, Gangavarapu S, Caillier SJ, Santaniello A, Isobe N, Hollenbach JA, Hauser SL, Oksenberg JR, Fernández-Vina MA

High-Resolution Characterization of KIR Genes in a Large North American Cohort Reveals Novel Details of Structural and Sequence Diversity.

Frontiers in immunology

Amorim LM, Augusto DG, Nemat-Gorgani N, Montero-Martin G, Marin WM, Shams H, Dandekar R, Caillier S, Parham P, Fernández-Viña MA, Oksenberg JR, Norman PJ, Hollenbach JA

Behçet disease, New insights in disease associations and manifestations. A next generation sequencing study.

Clinical and experimental immunology

Elfishawi M, Mossallam G, Augusto D, Montero-Martin G, de Bruin H, Van de Pasch L, Norman PJ, Rozemuller E, Fernandez-Vina M, Abrudescu A, Hollenbach JA, Zaky K, Elfishawi S

A splice acceptor variant in HLA-DRA affects the conformation and cellular localization of the class II DR alpha-chain.

Immunology

Didonna A, Damotte V, Shams H, Matsunaga A, Caillier SJ, Dandekar R, Misra MK, Mofrad MRK, Oksenberg JR, Hollenbach JA

Single Nucleotide Polymorphism in KIR2DL1 Is Associated With HLA-C Expression in Global Populations.

Frontiers in immunology

Vargas LB, Dourado RM, Amorim LM, Ho B, Calonga-Solís V, Issler HC, Marin WM, Beltrame MH, Petzl-Erler ML, Hollenbach JA, Augusto DG

Killer Cell Immunoglobulin-like Receptor Variants Are Associated with Protection from Symptoms Associated with More Severe Course in Parkinson Disease.

Journal of immunology (Baltimore, Md. : 1950)

Anderson KM, Augusto DG, Dandekar R, Shams H, Zhao C, Yusufali T, Montero-Martín G, Marin WM, Nemat-Gorgani N, Creary LE, Caillier S, Mofrad MRK, Parham P, Fernández-Viña M, Oksenberg JR, Norman PJ, Hollenbach JA

KIR Variation in Iranians Combines High Haplotype and Allotype Diversity With an Abundance of Functional Inhibitory Receptors.

Frontiers in immunology

Alicata C, Ashouri E, Nemat-Gorgani N, Guethlein LA, Marin WM, Tao S, Moretta L, Hollenbach JA, Trowsdale J, Traherne JA, Ghaderi A, Parham P, Norman PJ

Validation of a consumer-grade activity monitor for continuous daily activity monitoring in individuals with multiple sclerosis.

Multiple sclerosis journal - experimental, translational and clinical

Block VJ, Zhao C, Hollenbach JA, Olgin JE, Marcus GM, Pletcher MJ, Henry R, Gelfand JM, Cree BA

Association Between Serum Neurofilament Light Chain Levels and Long-term Disease Course Among Patients With Multiple Sclerosis Followed up for 12 Years.

JAMA neurology

Cantó E, Barro C, Zhao C, Caillier SJ, Michalak Z, Bove R, Tomic D, Santaniello A, Häring DA, Hollenbach J, Henry RG, Cree BAC, Kappos L, Leppert D, Hauser SL, Benkert P, Oksenberg JR, Kuhle J

Next-generation sequencing reveals new information about HLA allele and haplotype diversity in a large European American population.

Human immunology

Creary LE, Gangavarapu S, Mallempati KC, Montero-Martín G, Caillier SJ, Santaniello A, Hollenbach JA, Oksenberg JR, Fernández-Viña MA

Fluctuating and Geographically Specific Selection Characterize Rapid Evolution of the Human KIR Region.

Frontiers in immunology

Augusto DG, Norman PJ, Dandekar R, Hollenbach JA

A specific amino acid motif of HLA-DRB1 mediates risk and interacts with smoking history in Parkinson's disease.

Proceedings of the National Academy of Sciences of the United States of America

Hollenbach JA, Norman PJ, Creary LE, Damotte V, Montero-Martin G, Caillier S, Anderson KM, Misra MK, Nemat-Gorgani N, Osoegawa K, Santaniello A, Renschen A, Marin WM, Dandekar R, Parham P, Tanner CM, Hauser SL, Fernandez-Viña M, Oksenberg JR

Association of Continuous Assessment of Step Count by Remote Monitoring With Disability Progression Among Adults With Multiple Sclerosis.

JAMA network open

Block VJ, Bove R, Zhao C, Garcha P, Graves J, Romeo AR, Green AJ, Allen DD, Hollenbach JA, Olgin JE, Marcus GM, Pletcher MJ, Cree BAC, Gelfand JM

Conservation, Extensive Heterozygosity, and Convergence of Signaling Potential All Indicate a Critical Role for KIR3DL3 in Higher Primates.

Frontiers in immunology

Leaton LA, Shortt J, Kichula KM, Tao S, Nemat-Gorgani N, Mentzer AJ, Oppenheimer SJ, Deng Z, Hollenbach JA, Gignoux CR, Guethlein LA, Parham P, Carrington M, Norman PJ

Consumer (dis-)interest in Genetic Ancestry Testing: The roles of race, immigration, and ancestral certainty.

New Genetics and Society

Horowitz AL, Saperstein A, Little J, Maiers M, Hollenbach JA

Allele-Level KIR Genotyping of More Than a Million Samples: Workflow, Algorithm, and Observations.

Frontiers in immunology

Wagner I, Schefzyk D, Pruschke J, Schöfl G, Schöne B, Gruber N, Lang K, Hofmann J, Gnahm C, Heyn B, Marin WM, Dandekar R, Hollenbach JA, Schetelig J, Pingel J, Norman PJ, Sauter J, Schmidt AH, Lange V

Cost-effective and fast KIR gene-content genotyping by multiplex melting curve analysis.

HLA

Amorim LM, Santos THS, Hollenbach JA, Norman PJ, Marin WM, Dandekar R, de Souza Fonseca Ribeiro EM, Petzl-Erler ML, Augusto DG

Report from the Killer-cell Immunoglobulin-like Receptors (KIR) component of the 17th International HLA and Immunogenetics Workshop.

Human immunology

Misra MK, Augusto DG, Montero Martin G, Nemat-Gorgani N, Sauter J, Hofmann JA, Traherne JA, González-Quezada B, Gorodezky C, Bultitude W, Marin W, Vierra-Green C, Anderson KM, Balas A, Caro-Oleas JL, Cisneros E, Colucci F, Dandekar R, Elfishawi S, Fernández-Viña MA, Fouda M, González-Fernández R, Große A, Herrero-Mata MJ, Hollenbach SQ, Marsh SG, Mentzer A, Middleton D, Moffett A, Moreno-Hidalgo MA, Mossallam G, Nakimuli A, Oksenberg JR, Oppenheimer SJ, Parham P, Petzl-Erler ML, Planelles D, Sánchez-García F, Sánchez-Gordo F, Schmidt AH, Trowsdale J, Vargas LB, Vicario JL, Vilches C, Norman PJ, Hollenbach JA

Harnessing electronic medical records to advance research on multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England)

Damotte V, Lizée A, Tremblay M, Agrawal A, Khankhanian P, Santaniello A, Gomez R, Lincoln R, Tang W, Chen T, Lee N, Villoslada P, Hollenbach JA, Bevan CD, Graves J, Bove R, Goodin DS, Green AJ, Baranzini SE, Cree BA, Henry RG, Hauser SL, Gelfand JM, Gourraud PA

The immunogenetics of Neurological Disease.

Immunology

Misra MK, Damotte V, Hollenbach JA

Significant variation between SNP-based HLA imputations in diverse populations: the last mile is the hardest.

The pharmacogenomics journal

Pappas DJ, Lizee A, Paunic V, Beutner KR, Motyer A, Vukcevic D, Leslie S, Biesiada J, Meller J, Taylor KD, Zheng X, Zhao LP, Gourraud PA, Hollenbach JA, Mack SJ, Maiers M

Sequences of 95 human MHC haplotypes reveal extreme coding variation in genes other than highly polymorphic HLA class I and II.

Genome research

Norman PJ, Norberg SJ, Guethlein LA, Nemat-Gorgani N, Royce T, Wroblewski EE, Dunn T, Mann T, Alicata C, Hollenbach JA, Chang W, Shults Won M, Gunderson KL, Abi-Rached L, Ronaghi M, Parham P

Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case-control study.

PLoS medicine

Steele NZ, Carr JS, Bonham LW, Geier EG, Damotte V, Miller ZA, Desikan RS, Boehme KL, Mukherjee S, Crane PK, Kauwe JS, Kramer JH, Miller BL, Coppola G, Hollenbach JA, Huang Y, Yokoyama JS

Defining KIR and HLA Class I Genotypes at Highest Resolution via High-Throughput Sequencing.

American journal of human genetics

Norman PJ, Hollenbach JA, Nemat-Gorgani N, Marin WM, Norberg SJ, Ashouri E, Jayaraman J, Wroblewski EE, Trowsdale J, Rajalingam R, Oksenberg JR, Chiaroni J, Guethlein LA, Traherne JA, Ronaghi M, Parham P

Association of HLA Genetic Risk Burden With Disease Phenotypes in Multiple Sclerosis.

JAMA neurology

Isobe N, Keshavan A, Gourraud PA, Zhu AH, Datta E, Schlaeger R, Caillier SJ, Santaniello A, Lizée A, Himmelstein DS, Baranzini SE, Hollenbach J, Cree BA, Hauser SL, Oksenberg JR, Henry RG

Multidimensional reduction of multicentric cohort heterogeneity: An alternative method to increase statistical power and robustness.

Human immunology

Le Gall C, Laurent J, Vince N, Lizee A, Agrawal A, Walencik A, Rettman P, Gagne K, Retiere C, Hollenbach J, Cesbron A, Limou S, Gourraud PA

Molecular Pathology in Clinical Practice

Molecular HLA Typing

Malek Kamoun, Jill A Hollenbach, Steven J Mack, Thomas M Williams

The GL service: Web service to exchange GL string encoded HLA & KIR genotypes with complete and accurate allele and genotype ambiguity.

Human immunology

Milius RP, Heuer M, George M, Pollack J, Hollenbach JA, Mack SJ, Maiers M

KIR haplotypes are associated with late-onset type 1 diabetes in European-American families.

Genes and immunity

Traherne JA, Jiang W, Valdes AM, Hollenbach JA, Jayaraman J, Lane JA, Johnson C, Trowsdale J, Noble JA

Minimum information for reporting next generation sequence genotyping (MIRING): Guidelines for reporting HLA and KIR genotyping via next generation sequencing.

Human immunology

Mack SJ, Milius RP, Gifford BD, Sauter J, Hofmann J, Osoegawa K, Robinson J, Groeneweg M, Turenchalk GS, Adai A, Holcomb C, Rozemuller EH, Penning MT, Heuer ML, Wang C, Salit ML, Schmidt AH, Parham PR, Müller C, Hague T, Fischer G, Fernandez-Vina M, Hollenbach JA, Norman PJ, Maiers M

Histoimmunogenetics Markup Language 1.0: Reporting next generation sequencing-based HLA and KIR genotyping.

Human immunology

Milius RP, Heuer M, Valiga D, Doroschak KJ, Kennedy CJ, Bolon YT, Schneider J, Pollack J, Kim HR, Cereb N, Hollenbach JA, Mack SJ, Maiers M

Loss and Gain of Natural Killer Cell Receptor Function in an African Hunter-Gatherer Population.

PLoS genetics

Hilton HG, Norman PJ, Nemat-Gorgani N, Goyos A, Hollenbach JA, Henn BM, Gignoux CR, Guethlein LA, Parham P

Very long haplotype tracts characterized at high resolution from HLA homozygous cell lines.

Immunogenetics

Norman PJ, Norberg SJ, Nemat-Gorgani N, Royce T, Hollenbach JA, Shults Won M, Guethlein LA, Gunderson KL, Ronaghi M, Parham P

The immunogenetics of multiple sclerosis: A comprehensive review.

Journal of autoimmunity

Hollenbach JA, Oksenberg JR

HLA class II genotypes are not associated with age related macular degeneration in a case-control, population-based study.

Human immunology

Pappas D, Hollenbach J, Coleman AL, Gorin MB, Yu F, Williams K, Noble J, Tranah GJ

KIR diversity in Maori and Polynesians: populations in which HLA-B is not a significant KIR ligand.

Immunogenetics

Nemat-Gorgani N, Edinur HA, Hollenbach JA, Traherne JA, Dunn PP, Chambers GK, Parham P, Norman PJ

Validation of statistical imputation of allele-level multilocus phased genotypes from ambiguous HLA assignments.

Tissue antigens

Madbouly A, Gragert L, Freeman J, Leahy N, Gourraud PA, Hollenbach JA, Kamoun M, Fernandez-Vina M, Maiers M

Co-evolution of human leukocyte antigen (HLA) class I ligands with killer-cell immunoglobulin-like receptors (KIR) in a genetically diverse population of sub-Saharan Africans.

PLoS genetics

Norman PJ, Hollenbach JA, Nemat-Gorgani N, Guethlein LA, Hilton HG, Pando MJ, Koram KA, Riley EM, Abi-Rached L, Parham P

Genotype List String: a grammar for describing HLA and KIR genotyping results in a text string.

Tissue antigens

Milius RP, Mack SJ, Hollenbach JA, Pollack J, Heuer ML, Gragert L, Spellman S, Guethlein LA, Trachtenberg EA, Cooley S, Bochtler W, Mueller CR, Robinson J, Marsh SG, Maiers M

Common and well-documented HLA alleles: 2012 update to the CWD catalogue.

Tissue antigens

Mack SJ, Cano P, Hollenbach JA, He J, Hurley CK, Middleton D, Moraes ME, Pereira SE, Kempenich JH, Reed EF, Setterholm M, Smith AG, Tilanus MG, Torres M, Varney MD, Voorter CE, Fischer GF, Fleischhauer K, Goodridge D, Klitz W, Little AM, Maiers M, Marsh SG, Müller CR, Noreen H, Rozemuller EH, Sanchez-Mazas A, Senitzer D, Trachtenberg E, Fernandez-Vina M

16(th) IHIW: immunogenomic data-management methods. report from the immunogenomic data analysis working group (IDAWG).

International journal of immunogenetics

Hollenbach JA, Holcomb C, Hurley CK, Mabdouly A, Maiers M, Noble JA, Robinson J, Schmidt AH, Shi L, Turner V, Yao Y, Mack SJ

16(th) IHIW: population global distribution of killer immunoglobulin-like receptor (KIR) and ligands.

International journal of immunogenetics

Hollenbach JA, Augusto DG, Alaez C, Bubnova L, Fae I, Fischer G, Gonzalez-Galarza FF, Gorodezky C, Karabon L, Kusnierczyk P, Noble J, Rickards O, Roberts C, Schaffer M, Shi L, Tavoularis S, Trachtenberg E, Yao Y, Middleton D

16(th) IHIW: extending the number of resources and bioinformatics analysis for the investigation of HLA rare alleles.

International journal of immunogenetics

Gonzalez-Galarza FF, Mack SJ, Hollenbach J, Fernandez-Vina M, Setterholm M, Kempenich J, Marsh SG, Jones AR, Middleton D

Allele-level haplotype frequencies and pairwise linkage disequilibrium for 14 KIR loci in 506 European-American individuals.

PloS one

Vierra-Green C, Roe D, Hou L, Hurley CK, Rajalingam R, Reed E, Lebedeva T, Yu N, Stewart M, Noreen H, Hollenbach JA, Guethlein LA, Wang T, Spellman S, Maiers M

Killer cell immunoglobulin-like receptor (KIR) gene content variation in the HGDP-CEPH populations.

Immunogenetics

Hollenbach JA, Nocedal I, Ladner MB, Single RM, Trachtenberg EA

A combined DPA1~DPB1 amino acid epitope is the primary unit of selection on the HLA-DP heterodimer.

Immunogenetics

Hollenbach JA, Madbouly A, Gragert L, Vierra-Green C, Flesch S, Spellman S, Begovich A, Noreen H, Trachtenberg E, Williams T, Yu N, Shaw B, Fleischhauer K, Fernandez-Vina M, Maiers M

Tracking human migrations by the analysis of the distribution of HLA alleles, lineages and haplotypes in closed and open populations.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences

Fernandez Vina MA, Hollenbach JA, Lyke KE, Sztein MB, Maiers M, Klitz W, Cano P, Mack S, Single R, Brautbar C, Israel S, Raimondi E, Khoriaty E, Inati A, Andreani M, Testi M, Moraes ME, Thomson G, Stastny P, Cao K

Analytical methods for disease association studies with immunogenetic data.

Methods in molecular biology (Clifton, N.J.)

Hollenbach JA, Mack SJ, Thomson G, Gourraud PA

Analytical methods for immunogenetic population data.

Methods in molecular biology (Clifton, N.J.)

Mack SJ, Gourraud PA, Single RM, Thomson G, Hollenbach JA

Standard methods for the management of immunogenetic data.

Methods in molecular biology (Clifton, N.J.)

Gourraud PA, Hollenbach JA, Barnetche T, Single RM, Mack SJ

A community standard for immunogenomic data reporting and analysis: proposal for a STrengthening the REporting of Immunogenomic Studies statement.

Tissue antigens

Hollenbach JA, Mack SJ, Gourraud PA, Single RM, Maiers M, Middleton D, Thomson G, Marsh SG, Varney MD

Immunogenetics as a tool in anthropological studies.

Immunology

Sanchez-Mazas A, Fernandez-Viña M, Middleton D, Hollenbach JA, Buhler S, Di D, Rajalingam R, Dugoujon JM, Mack SJ, Thorsby E

Association of HLA alleles with Plasmodium falciparum severity in Malian children.

Tissue antigens

Lyke KE, Fernández-Vina MA, Cao K, Hollenbach J, Coulibaly D, Kone AK, Guindo A, Burdett LA, Hartzman RJ, Wahl AR, Hildebrand WH, Doumbo OK, Plowe CV, Sztein MB

Juvenile idiopathic arthritis and HLA class I and class II interactions and age-at-onset effects.

Arthritis and rheumatism

Hollenbach JA, Thompson SD, Bugawan TL, Ryan M, Sudman M, Marion M, Langefeld CD, Thomson G, Erlich HA, Glass DN

Report from the killer immunoglobulin-like receptor (KIR) anthropology component of the 15th International Histocompatibility Workshop: worldwide variation in the KIR loci and further evidence for the co-evolution of KIR and HLA.

Tissue antigens

Hollenbach JA, Meenagh A, Sleator C, Alaez C, Bengoche M, Canossi A, Contreras G, Creary L, Evseeva I, Gorodezky C, Hardie RA, Karlsen TH, Lie B, Luo M, Martinetti M, Navarette C, de Oliveira DC, Ozzella G, Pasi A, Pavlova E, Pinto S, Porto LC, Santos P, Slavcev A, Srinak D, Tavoularis S, Tonks S, Trachtenberg E, Vejbaesya S, Middleton D

Sequence feature variant type (SFVT) analysis of the HLA genetic association in juvenile idiopathic arthritis.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing

Thomson G, Marthandan N, Hollenbach JA, Mack SJ, Erlich HA, Single RM, Waller MJ, Marsh SG, Guidry PA, Karp DR, Scheuermann RH, Thompson SD, Glass DN, Helmberg W

Susceptibility to Crohn's disease is mediated by KIR2DL2/KIR2DL3 heterozygosity and the HLA-C ligand.

Immunogenetics

Hollenbach JA, Ladner MB, Saeteurn K, Taylor KD, Mei L, Haritunians T, McGovern DP, Erlich HA, Rotter JI, Trachtenberg EA

HLA class I (A, B, C) and class II (DRB1, DQA1, DQB1, DPB1) alleles and haplotypes in the Han from southern China.

Tissue antigens

Trachtenberg E, Vinson M, Hayes E, Hsu YM, Houtchens K, Erlich H, Klitz W, Hsia Y, Hollenbach J

Genetic variability and linkage disequilibrium within the HLA-DP region: analysis of 15 different populations.

Tissue antigens

Begovich AB, Moonsamy PV, Mack SJ, Barcellos LF, Steiner LL, Grams S, Suraj-Baker V, Hollenbach J, Trachtenberg E, Louie L, Zimmerman P, Hill AV, Stoneking M, Sasazuki T, Konenkov VI, Sartakova ML, Titanji VP, Rickards O, Klitz W

HLA diversity, differentiation, and haplotype evolution in Mesoamerican Natives.

Human immunology

Hollenbach JA, Thomson G, Cao K, Fernandez-Vina M, Erlich HA, Bugawan TL, Winkler C, Winter M, Klitz W

Hardy-Weinberg testing for HLA class II (DRB1, DQA1, DQB1, and DPB1) loci in 26 human ethnic groups.

Tissue antigens

Chen JJ, Hollenbach JA, Trachtenberg EA, Just JJ, Carrington M, Rønningen KS, Begovich A, King MC, McWeeney S, Mack SJ, Erlich HA, Thomson G