Jill Hollenbach, PhD, MPH

Associate Professor
Department of Neurology

Dr. Hollenbach is Associate Professor in the Department of Neurology at UC San Francisco. She was raised in California and completed her undergraduate studies in Physiology and Masters degree in Public Health at the University of California, Berkeley. After several years working in public health in the Caribbean and Northern California, she returned to UC Berkeley for her doctoral studies in Immunology, with an emphasis on population genetics of the human leukocyte antigen (HLA) system. Throughout her career Dr. Hollenbach’s work has continued to focus on the HLA loci and killer immunoglobulin-like receptor (KIR) genes in disease association, transplantation and evolutionary studies, and in the last several years her interest has widened to include exploration of the intersection between self-identity and genomics. Current NIH funded projects include the development of standards and software for immunogenetic data, examination of the extended MHC in multiple sclerosis and Alzheimer's disease, and KIR variation across neurological disease. 

UCSF Profiles

UCSF Bioinformatics Graduate Program

UCSF Institute for Human Genetics

UCSF Multiple Sclerosis Research Group

Women In Science @UCSF

Immunogenomic Data Analysis Working Group (IDAWG)

International Histocompatibility and Immunogenetics Workshop Council

Publications: 

Validation of a consumer-grade activity monitor for continuous daily activity monitoring in individuals with multiple sclerosis.

Multiple sclerosis journal - experimental, translational and clinical

Block VJ, Zhao C, Hollenbach JA, Olgin JE, Marcus GM, Pletcher MJ, Henry R, Gelfand JM, Cree BA

Association Between Serum Neurofilament Light Chain Levels and Long-term Disease Course Among Patients With Multiple Sclerosis Followed up for 12 Years.

JAMA neurology

Cantó E, Barro C, Zhao C, Caillier SJ, Michalak Z, Bove R, Tomic D, Santaniello A, Häring DA, Hollenbach J, Henry RG, Cree BAC, Kappos L, Leppert D, Hauser SL, Benkert P, Oksenberg JR, Kuhle J

Next-generation sequencing reveals new information about HLA allele and haplotype diversity in a large European American population.

Human immunology

Creary LE, Gangavarapu S, Mallempati KC, Montero-Martín G, Caillier SJ, Santaniello A, Hollenbach JA, Oksenberg JR, Fernández-Viña MA

Fluctuating and Geographically Specific Selection Characterize Rapid Evolution of the Human KIR Region.

Frontiers in immunology

Augusto DG, Norman PJ, Dandekar R, Hollenbach JA

A specific amino acid motif of HLA-DRB1 mediates risk and interacts with smoking history in Parkinson's disease.

Proceedings of the National Academy of Sciences of the United States of America

Hollenbach JA, Norman PJ, Creary LE, Damotte V, Montero-Martin G, Caillier S, Anderson KM, Misra MK, Nemat-Gorgani N, Osoegawa K, Santaniello A, Renschen A, Marin WM, Dandekar R, Parham P, Tanner CM, Hauser SL, Fernandez-Viña M, Oksenberg JR

Association of Continuous Assessment of Step Count by Remote Monitoring With Disability Progression Among Adults With Multiple Sclerosis.

JAMA network open

Block VJ, Bove R, Zhao C, Garcha P, Graves J, Romeo AR, Green AJ, Allen DD, Hollenbach JA, Olgin JE, Marcus GM, Pletcher MJ, Cree BAC, Gelfand JM

Conservation, Extensive Heterozygosity, and Convergence of Signaling Potential All Indicate a Critical Role for KIR3DL3 in Higher Primates.

Frontiers in immunology

Leaton LA, Shortt J, Kichula KM, Tao S, Nemat-Gorgani N, Mentzer AJ, Oppenheimer SJ, Deng Z, Hollenbach JA, Gignoux CR, Guethlein LA, Parham P, Carrington M, Norman PJ

Consumer (dis-)interest in Genetic Ancestry Testing: The roles of race, immigration, and ancestral certainty.

New Genetics and Society

Horowitz AL, Saperstein A, Little J, Maiers M, Hollenbach JA

Allele-Level KIR Genotyping of More Than a Million Samples: Workflow, Algorithm, and Observations.

Frontiers in immunology

Wagner I, Schefzyk D, Pruschke J, Schöfl G, Schöne B, Gruber N, Lang K, Hofmann J, Gnahm C, Heyn B, Marin WM, Dandekar R, Hollenbach JA, Schetelig J, Pingel J, Norman PJ, Sauter J, Schmidt AH, Lange V

Cost-effective and fast KIR gene-content genotyping by multiplex melting curve analysis.

HLA

Amorim LM, Santos THS, Hollenbach JA, Norman PJ, Marin WM, Dandekar R, de Souza Fonseca Ribeiro EM, Petzl-Erler ML, Augusto DG

Report from the Killer-cell Immunoglobulin-like Receptors (KIR) component of the 17th International HLA and Immunogenetics Workshop.

Human immunology

Misra MK, Augusto DG, Montero Martin G, Nemat-Gorgani N, Sauter J, Hofmann JA, Traherne JA, González-Quezada B, Gorodezky C, Bultitude W, Marin W, Vierra-Green C, Anderson KM, Balas A, Caro-Oleas JL, Cisneros E, Colucci F, Dandekar R, Elfishawi S, Fernández-Viña MA, Fouda M, González-Fernández R, Große A, Herrero-Mata MJ, Hollenbach SQ, Marsh SG, Mentzer A, Middleton D, Moffett A, Moreno-Hidalgo MA, Mossallam G, Nakimuli A, Oksenberg JR, Oppenheimer SJ, Parham P, Petzl-Erler ML, Planelles D, Sánchez-García F, Sánchez-Gordo F, Schmidt AH, Trowsdale J, Vargas LB, Vicario JL, Vilches C, Norman PJ, Hollenbach JA

Harnessing electronic medical records to advance research on multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England)

Damotte V, Lizée A, Tremblay M, Agrawal A, Khankhanian P, Santaniello A, Gomez R, Lincoln R, Tang W, Chen T, Lee N, Villoslada P, Hollenbach JA, Bevan CD, Graves J, Bove R, Goodin DS, Green AJ, Baranzini SE, Cree BA, Henry RG, Hauser SL, Gelfand JM, Gourraud PA

The immunogenetics of Neurological Disease.

Immunology

Misra MK, Damotte V, Hollenbach JA

Significant variation between SNP-based HLA imputations in diverse populations: the last mile is the hardest.

The pharmacogenomics journal

Pappas DJ, Lizee A, Paunic V, Beutner KR, Motyer A, Vukcevic D, Leslie S, Biesiada J, Meller J, Taylor KD, Zheng X, Zhao LP, Gourraud PA, Hollenbach JA, Mack SJ, Maiers M

Sequences of 95 human MHC haplotypes reveal extreme coding variation in genes other than highly polymorphic HLA class I and II.

Genome research

Norman PJ, Norberg SJ, Guethlein LA, Nemat-Gorgani N, Royce T, Wroblewski EE, Dunn T, Mann T, Alicata C, Hollenbach JA, Chang W, Shults Won M, Gunderson KL, Abi-Rached L, Ronaghi M, Parham P

Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case-control study.

PLoS medicine

Steele NZ, Carr JS, Bonham LW, Geier EG, Damotte V, Miller ZA, Desikan RS, Boehme KL, Mukherjee S, Crane PK, Kauwe JS, Kramer JH, Miller BL, Coppola G, Hollenbach JA, Huang Y, Yokoyama JS

Defining KIR and HLA Class I Genotypes at Highest Resolution via High-Throughput Sequencing.

American journal of human genetics

Norman PJ, Hollenbach JA, Nemat-Gorgani N, Marin WM, Norberg SJ, Ashouri E, Jayaraman J, Wroblewski EE, Trowsdale J, Rajalingam R, Oksenberg JR, Chiaroni J, Guethlein LA, Traherne JA, Ronaghi M, Parham P

Association of HLA Genetic Risk Burden With Disease Phenotypes in Multiple Sclerosis.

JAMA neurology

Isobe N, Keshavan A, Gourraud PA, Zhu AH, Datta E, Schlaeger R, Caillier SJ, Santaniello A, Lizée A, Himmelstein DS, Baranzini SE, Hollenbach J, Cree BA, Hauser SL, Oksenberg JR, Henry RG

Multidimensional reduction of multicentric cohort heterogeneity: An alternative method to increase statistical power and robustness.

Human immunology

Le Gall C, Laurent J, Vince N, Lizee A, Agrawal A, Walencik A, Rettman P, Gagne K, Retiere C, Hollenbach J, Cesbron A, Limou S, Gourraud PA

Molecular Pathology in Clinical Practice

Molecular HLA Typing

Malek Kamoun, Jill A Hollenbach, Steven J Mack, Thomas M Williams

The GL service: Web service to exchange GL string encoded HLA & KIR genotypes with complete and accurate allele and genotype ambiguity.

Human immunology

Milius RP, Heuer M, George M, Pollack J, Hollenbach JA, Mack SJ, Maiers M

KIR haplotypes are associated with late-onset type 1 diabetes in European-American families.

Genes and immunity

Traherne JA, Jiang W, Valdes AM, Hollenbach JA, Jayaraman J, Lane JA, Johnson C, Trowsdale J, Noble JA

Minimum information for reporting next generation sequence genotyping (MIRING): Guidelines for reporting HLA and KIR genotyping via next generation sequencing.

Human immunology

Mack SJ, Milius RP, Gifford BD, Sauter J, Hofmann J, Osoegawa K, Robinson J, Groeneweg M, Turenchalk GS, Adai A, Holcomb C, Rozemuller EH, Penning MT, Heuer ML, Wang C, Salit ML, Schmidt AH, Parham PR, Müller C, Hague T, Fischer G, Fernandez-Vina M, Hollenbach JA, Norman PJ, Maiers M

Histoimmunogenetics Markup Language 1.0: Reporting next generation sequencing-based HLA and KIR genotyping.

Human immunology

Milius RP, Heuer M, Valiga D, Doroschak KJ, Kennedy CJ, Bolon YT, Schneider J, Pollack J, Kim HR, Cereb N, Hollenbach JA, Mack SJ, Maiers M

Loss and Gain of Natural Killer Cell Receptor Function in an African Hunter-Gatherer Population.

PLoS genetics

Hilton HG, Norman PJ, Nemat-Gorgani N, Goyos A, Hollenbach JA, Henn BM, Gignoux CR, Guethlein LA, Parham P

Very long haplotype tracts characterized at high resolution from HLA homozygous cell lines.

Immunogenetics

Norman PJ, Norberg SJ, Nemat-Gorgani N, Royce T, Hollenbach JA, Shults Won M, Guethlein LA, Gunderson KL, Ronaghi M, Parham P

The immunogenetics of multiple sclerosis: A comprehensive review.

Journal of autoimmunity

Hollenbach JA, Oksenberg JR

HLA class II genotypes are not associated with age related macular degeneration in a case-control, population-based study.

Human immunology

Pappas D, Hollenbach J, Coleman AL, Gorin MB, Yu F, Williams K, Noble J, Tranah GJ

KIR diversity in Maori and Polynesians: populations in which HLA-B is not a significant KIR ligand.

Immunogenetics

Nemat-Gorgani N, Edinur HA, Hollenbach JA, Traherne JA, Dunn PP, Chambers GK, Parham P, Norman PJ

Validation of statistical imputation of allele-level multilocus phased genotypes from ambiguous HLA assignments.

Tissue antigens

Madbouly A, Gragert L, Freeman J, Leahy N, Gourraud PA, Hollenbach JA, Kamoun M, Fernandez-Vina M, Maiers M

Co-evolution of human leukocyte antigen (HLA) class I ligands with killer-cell immunoglobulin-like receptors (KIR) in a genetically diverse population of sub-Saharan Africans.

PLoS genetics

Norman PJ, Hollenbach JA, Nemat-Gorgani N, Guethlein LA, Hilton HG, Pando MJ, Koram KA, Riley EM, Abi-Rached L, Parham P

Genotype List String: a grammar for describing HLA and KIR genotyping results in a text string.

Tissue antigens

Milius RP, Mack SJ, Hollenbach JA, Pollack J, Heuer ML, Gragert L, Spellman S, Guethlein LA, Trachtenberg EA, Cooley S, Bochtler W, Mueller CR, Robinson J, Marsh SG, Maiers M

Common and well-documented HLA alleles: 2012 update to the CWD catalogue.

Tissue antigens

Mack SJ, Cano P, Hollenbach JA, He J, Hurley CK, Middleton D, Moraes ME, Pereira SE, Kempenich JH, Reed EF, Setterholm M, Smith AG, Tilanus MG, Torres M, Varney MD, Voorter CE, Fischer GF, Fleischhauer K, Goodridge D, Klitz W, Little AM, Maiers M, Marsh SG, Müller CR, Noreen H, Rozemuller EH, Sanchez-Mazas A, Senitzer D, Trachtenberg E, Fernandez-Vina M

16(th) IHIW: immunogenomic data-management methods. report from the immunogenomic data analysis working group (IDAWG).

International journal of immunogenetics

Hollenbach JA, Holcomb C, Hurley CK, Mabdouly A, Maiers M, Noble JA, Robinson J, Schmidt AH, Shi L, Turner V, Yao Y, Mack SJ

16(th) IHIW: population global distribution of killer immunoglobulin-like receptor (KIR) and ligands.

International journal of immunogenetics

Hollenbach JA, Augusto DG, Alaez C, Bubnova L, Fae I, Fischer G, Gonzalez-Galarza FF, Gorodezky C, Karabon L, Kusnierczyk P, Noble J, Rickards O, Roberts C, Schaffer M, Shi L, Tavoularis S, Trachtenberg E, Yao Y, Middleton D

16(th) IHIW: extending the number of resources and bioinformatics analysis for the investigation of HLA rare alleles.

International journal of immunogenetics

Gonzalez-Galarza FF, Mack SJ, Hollenbach J, Fernandez-Vina M, Setterholm M, Kempenich J, Marsh SG, Jones AR, Middleton D

Allele-level haplotype frequencies and pairwise linkage disequilibrium for 14 KIR loci in 506 European-American individuals.

PloS one

Vierra-Green C, Roe D, Hou L, Hurley CK, Rajalingam R, Reed E, Lebedeva T, Yu N, Stewart M, Noreen H, Hollenbach JA, Guethlein LA, Wang T, Spellman S, Maiers M

Killer cell immunoglobulin-like receptor (KIR) gene content variation in the HGDP-CEPH populations.

Immunogenetics

Hollenbach JA, Nocedal I, Ladner MB, Single RM, Trachtenberg EA

A combined DPA1~DPB1 amino acid epitope is the primary unit of selection on the HLA-DP heterodimer.

Immunogenetics

Hollenbach JA, Madbouly A, Gragert L, Vierra-Green C, Flesch S, Spellman S, Begovich A, Noreen H, Trachtenberg E, Williams T, Yu N, Shaw B, Fleischhauer K, Fernandez-Vina M, Maiers M

Tracking human migrations by the analysis of the distribution of HLA alleles, lineages and haplotypes in closed and open populations.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences

Fernandez Vina MA, Hollenbach JA, Lyke KE, Sztein MB, Maiers M, Klitz W, Cano P, Mack S, Single R, Brautbar C, Israel S, Raimondi E, Khoriaty E, Inati A, Andreani M, Testi M, Moraes ME, Thomson G, Stastny P, Cao K

Analytical methods for disease association studies with immunogenetic data.

Methods in molecular biology (Clifton, N.J.)

Hollenbach JA, Mack SJ, Thomson G, Gourraud PA

Analytical methods for immunogenetic population data.

Methods in molecular biology (Clifton, N.J.)

Mack SJ, Gourraud PA, Single RM, Thomson G, Hollenbach JA

Standard methods for the management of immunogenetic data.

Methods in molecular biology (Clifton, N.J.)

Gourraud PA, Hollenbach JA, Barnetche T, Single RM, Mack SJ

A community standard for immunogenomic data reporting and analysis: proposal for a STrengthening the REporting of Immunogenomic Studies statement.

Tissue antigens

Hollenbach JA, Mack SJ, Gourraud PA, Single RM, Maiers M, Middleton D, Thomson G, Marsh SG, Varney MD

Immunogenetics as a tool in anthropological studies.

Immunology

Sanchez-Mazas A, Fernandez-Viña M, Middleton D, Hollenbach JA, Buhler S, Di D, Rajalingam R, Dugoujon JM, Mack SJ, Thorsby E

Association of HLA alleles with Plasmodium falciparum severity in Malian children.

Tissue antigens

Lyke KE, Fernández-Vina MA, Cao K, Hollenbach J, Coulibaly D, Kone AK, Guindo A, Burdett LA, Hartzman RJ, Wahl AR, Hildebrand WH, Doumbo OK, Plowe CV, Sztein MB

Juvenile idiopathic arthritis and HLA class I and class II interactions and age-at-onset effects.

Arthritis and rheumatism

Hollenbach JA, Thompson SD, Bugawan TL, Ryan M, Sudman M, Marion M, Langefeld CD, Thomson G, Erlich HA, Glass DN

Report from the killer immunoglobulin-like receptor (KIR) anthropology component of the 15th International Histocompatibility Workshop: worldwide variation in the KIR loci and further evidence for the co-evolution of KIR and HLA.

Tissue antigens

Hollenbach JA, Meenagh A, Sleator C, Alaez C, Bengoche M, Canossi A, Contreras G, Creary L, Evseeva I, Gorodezky C, Hardie RA, Karlsen TH, Lie B, Luo M, Martinetti M, Navarette C, de Oliveira DC, Ozzella G, Pasi A, Pavlova E, Pinto S, Porto LC, Santos P, Slavcev A, Srinak D, Tavoularis S, Tonks S, Trachtenberg E, Vejbaesya S, Middleton D

Sequence feature variant type (SFVT) analysis of the HLA genetic association in juvenile idiopathic arthritis.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing

Thomson G, Marthandan N, Hollenbach JA, Mack SJ, Erlich HA, Single RM, Waller MJ, Marsh SG, Guidry PA, Karp DR, Scheuermann RH, Thompson SD, Glass DN, Helmberg W

Susceptibility to Crohn's disease is mediated by KIR2DL2/KIR2DL3 heterozygosity and the HLA-C ligand.

Immunogenetics

Hollenbach JA, Ladner MB, Saeteurn K, Taylor KD, Mei L, Haritunians T, McGovern DP, Erlich HA, Rotter JI, Trachtenberg EA

HLA class I (A, B, C) and class II (DRB1, DQA1, DQB1, DPB1) alleles and haplotypes in the Han from southern China.

Tissue antigens

Trachtenberg E, Vinson M, Hayes E, Hsu YM, Houtchens K, Erlich H, Klitz W, Hsia Y, Hollenbach J

Genetic variability and linkage disequilibrium within the HLA-DP region: analysis of 15 different populations.

Tissue antigens

Begovich AB, Moonsamy PV, Mack SJ, Barcellos LF, Steiner LL, Grams S, Suraj-Baker V, Hollenbach J, Trachtenberg E, Louie L, Zimmerman P, Hill AV, Stoneking M, Sasazuki T, Konenkov VI, Sartakova ML, Titanji VP, Rickards O, Klitz W

HLA diversity, differentiation, and haplotype evolution in Mesoamerican Natives.

Human immunology

Hollenbach JA, Thomson G, Cao K, Fernandez-Vina M, Erlich HA, Bugawan TL, Winkler C, Winter M, Klitz W

Hardy-Weinberg testing for HLA class II (DRB1, DQA1, DQB1, and DPB1) loci in 26 human ethnic groups.

Tissue antigens

Chen JJ, Hollenbach JA, Trachtenberg EA, Just JJ, Carrington M, Rønningen KS, Begovich A, King MC, McWeeney S, Mack SJ, Erlich HA, Thomson G