This project focuses on the development of a novel bioinformatics pipeline for genotyping of the genes located within the leukocyte receptor complex (LRC) region of the human chromosome (19q13.4). Adapted from the PING software, this custom pipeline processes reads obtained from the targeted sequencing of the LRC region and infers the genotypes for each LRC locus of interest. The pipeline incorporates genomic sequences obtained from the human pan-genome reference consortium (HPRC) to implement filters that capture all variants of homologous genes, thereby forcing the selection of reads that exclusively to specific loci. This pipeline enables us to characterize and study the genomic variations across all the genes in the LRC, most notably in the genes that encode for leukocyte immunoglobulin like receptor (LILR) and leukocyte-associated immunoglobulin-like receptor (LAIR) molecules.