Immunogenetics of emerging pathogens

In collaboration with the Virgin Islands Department of Health and the Centers for Disease Control, our lab is examining the the role of immunogenetic variation in vulnerability to infection and long-term sequelae from Chikungunya and Zika virus. This recently initiated project involves high-resolution sequencing of HLA and KIR, coupled with serology and longterm surveillance and follow-up of infected individuals across the United States Virgin Islands.

In collaboration with the Universidade Federal do Rio Grande do Sul, Brazil, we are conducting a case-control study on infants exposed to Zika virus in utero to identify variants in HLA and KIR that could be associated to the Congenital Zika Syndrome.